Van den Berghe G. Thyroid. 2014 Oct;24(10):1456-1465 PMID: 24845024 Critically ill patients typically present with low or low-normal plasma thyroxine, low plasma triiodothyronine (T3), increased plasma reverse T3 (rT3) concentrations, in the absence of a rise in thyrotropin (TSH). This constellation is referred to as nonthyroidal illness syndrome (NTI). Although it is long known that […]
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Planck T1, Shahida B, Parikh H, Ström K, Asman P, Brorson H, Hallengren B, Lantz M. Thyroid. 2014 Oct;24(10):1524-1532.. PMID: 25135760 Cigarette smoking is a risk factor for the development of Graves’ ophthalmopathy (GO). In a previous study of gene expression in intraorbital fat, adipocyte-related immediate early genes (IEGs) were overexpressed in patients with GO […]
.Li C, Aragon Han P, Lee KC, Lee LC, Fox AC, Beninato T, Thiess M, Dy BM, Sebo TJ, Thompson GB, Grant CS, Giordano TJ, Gauger PG, Doherty GM, Fahey TJ 3rd, Bishop J, Eshleman JR, Umbricht CB, Schneider EB, Zeiger MA. J Clin Endocrinol Metab. 2013 Sep;98(9):3702-12. Existing evidence is controversial regarding the association between BRAF mutation status and aggressive features of papillary thyroid cancer (PTC). Specifically, no study has incorporated multiple surgical practices […]
Taylor PN, Razvi S, Pearce SH, Dayan CM. J Clin Endocrinol Metab. 2013 Sep;98(9):3562-71. Overt thyroid disease is associated with profound adverse health outcomes; however, data are conflicting for studies of borderline/subclinical thyroid dysfunction. Many studies of subclinical thyroid disease have had low power and were prone to selection bias. In contrast, large datasets are available from community studies […]
Gharib H, Hegedüs L, Pacella CM, Baek JH, Papini E. J Clin Endocrinol Metab. 2013 Oct;98(10):3949-57. Nodular thyroid disease is very common. Most nodules are asymptomatic, are benign by fine-needle aspiration, remain stable, and can be followed by observation alone in the majority of the patients. Occasionally, nodules grow or cause symptoms requiring treatment. So far, surgery has been our […]
Retrobulbar inflammation, adipogenesis, and acute orbital congestion in a preclinical female mouse model of Graves’ orbitopathy induced by thyrotropin receptor plasmid-in vivo electroporation. Moshkelgosha S, So PW, Deasy N, Diaz-Cano S, Banga JP. Endocrinology. 2013 Sep;154(9):3008-15. Graves’ orbitopathy (GO) is a complication in Graves’ disease (GD) but mechanistic insights into pathogenesis remain unresolved, hampered by lack of animal model. The […]
Increased mortality in patients with differentiated thyroid cancer associated with graves' disease.Pellegriti G, Mannarino C, Russo M, Terranova R, Marturano I, Vigneri R, Belfiore A. J Clin Endocrinol Metab. 2013 Mar;98(3):1014-21 We previously reported that differentiated thyroid cancer (DTC) has higher aggressiveness and poorer prognosis in patients with Graves' disease (GD) than DTC in euthyroid […]
Autoantibodies to the IGF1 Receptor in Graves' Orbitopathy.Minich WB, Dehina N, Welsink T, Schwiebert C, Morgenthaler NG, Köhrle J, Eckstein A, Schomburg L. J Clin Endocrinol Metab. 2013 Feb;98(2):752-60. doi: 10.1210/jc.2012-1771 Graves' disease (GD) is maintained by stimulating antibodies against the TSH receptor. Graves' orbitopathy (GO) is the main extrathyroidal manifestation of GD, potentially involving […]
Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study. J Clin Endocrinol Metab. 2012 Nov;97(11):3944-50. Waring AC, Arnold AM, Newman AB, Bùzková P, Hirsch C, Cappola AR. Data on thyroid function in the oldest old are sparse, and existing studies show conflicting evidence on the relationship between […]
Fetal free thyroxine concentrations in pregnant women with autoimmune thyroid disease. J Clin Endocrinol Metab. 2012 Nov;97(11):4014-21. Spremovic-Radjenovic S, Gudovic A, Lazovic G, Marinkovic J, Radunovic N, Ljubic A. Fetuses from mothers with autoimmune thyroid disease (AITD) may be affected by antithyroid antibodies, antithyroid drugs, and iodine. The study correlated fetal free T(4) (fT4) with […]
Efficacy and Safety of Three Different Cumulative Doses of Intravenous Methylprednisolone for Moderate to Severe and Active Graves’ Orbitopathy. J Clin Endocrinol Metab. 2012 Dec;97(12):4454-4463. Bartalena L, Krassas GE, Wiersinga W, Marcocci C, Salvi M, Daumerie C, Bournaud C, Stahl M, Sassi L, Veronesi G, Azzolini C, Boboridis KG, Mourits MP, Soeters MR, Baldeschi L, […]
Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges.17 Oct 2012 Persani L. luca.persani@unimi.it. J Clin Endocrinol Metab. 2012 Sep;97(9):3068-78. Central hypothyroidism (CH) is a particular hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. This condition raises several challenges for clinicians; therefore, a review of the most relevant findings on […]
Need for thyroidectomy in patients treated with radioactive iodide for benign thyroid disease.Villadsen MJ, Sørensen CH, Godballe C, Nygaard B. Dan Med Bull. 2011 Dec;58(12):A4343. ABSTRACT-Nodular toxic and non-toxic goitres are seen in approximately 15% of Danish women, and the pros and cons of thyroidectomy versus radioiodine (RI) therapy are often discussed. The purpose of […]
Outpatient Thyroid Remnant Ablation Using Repeated Low 131-Iodine Activities (740 MBq/20 mCi x 2) in Patients with Low-Risk Differentiated Thyroid Cancer. Clerc J, Bienvenu-Perrard M, Pichard de Malleray C, Dagousset F, Delbot T, Dreyfuss M, Groussin L, Marlowe RJ, Leger FA, Chevalier A. J Clin Endocrinol Metab. 2012 Jan 11. ABSTRACT- In low-risk differentiated thyroid […]
Outpatient Thyroid Remnant Ablation Using Repeated Low 131-Iodine Activities (740 MBq/20 mCi x 2) in Patients with Low-Risk Differentiated Thyroid Cancer. Clerc J, Bienvenu-Perrard M, Pichard de Malleray C, Dagousset F, Delbot T, Dreyfuss M, Groussin L, Marlowe RJ, Leger FA, Chevalier A. J Clin Endocrinol Metab. 2012 Jan 11. ABSTRACT- In low-risk differentiated thyroid […]
Not the Number but the Location of Lymph Nodes Matters for Recurrence Rate and Disease-Free Survival in Patients with Differentiated Thyroid Cancer. de Meer SG, Dauwan M, de Keizer B, Valk GD, Borel Rinkes IH, Vriens MR. World J Surg. 2012 Jan 20. ABSTRACT-Several Japanese studies have focused on identifying prognostic factors in patients with […]
A Mutation in the Thyroid Hormone Receptor Alpha Gene.Bochukova E, Schoenmakers N, Agostini M, Schoenmakers E, Rajanayagam O, Keogh JM, Henning E, Reinemund J, Gevers E, Sarri M, Downes K, Offiah A, Albanese A, Halsall D, Schwabe JW, Bain M, Lindley K, Muntoni F, Khadem FV, Dattani M, Farooqi IS, Gurnell M, Chatterjee K. N […]
TOPIC: Prenatal multivitamin pills Title: Iodine Content of U.S. Prenatal Multivitamins Authors: Leung AM, Braverman LE, Pino S, He X, & Pearce EN. Reference: Thyroid 18 (Suppl. 1) S-45, 2008 Abstract of a poster presented at the 79th Annual Meeting of the American Thyroid Association (Chicago, October 2008) Summary Background Adequate maternal iodine intake during […]
Valle LA , Kloos RT The prevalence of occult medullary thyroid carcinoma at autopsy. J Clin Endocrinol Metab. 2011 Jan;96(1):E109-13. Epub 2010 Oct 13. The prevalence of occult medullary thyroid carcinoma (MTC) in the general population is unknown but may be important when considering strategies to diagnose clinically relevant MTC in nodular goiter or other […]
James C. Sisson, John Freitas, Iain Ross McDougall, Lawrence T. Dauer, James R. Hurley, James D. Brierley, Charlotte H. Edinboro, David Rosenthal, Michael J. Thomas, Jason A Wexler, Ernest Asamoah, Anca M. Avram, Mira Milas, Carol Greenlee Thyroid. April 2011, 21(4): 335-346. The Most Commonly Occurring Papillary Thyroid Cancer in the United States Is Now […]
Bahn RS , Castro MR J Clin Endocrinol Metab. 2011 May;96(5):1202-12. Thyroid nodules are very common, and although the majority are benign, approximately 5% may harbor malignancy. The evaluation of the patient with solitary thyroid nodule is generally straightforward and will typically include measurement of serum TSH to assess thyroid function and fine-needle aspiration biopsy […]
Spencer C , Petrovic I , Fatemi S J Clin Endocrinol Metab. 2011 May;96(5):1283-91. Specimens have thyroglobulin antibody (TgAb) measured prior to thyroglobulin (Tg) testing because the qualitative TgAb status (positive or negative) determines risk for Tg assay interference, and the quantitative TgAb concentration serves as a surrogate tumor marker for differentiated thyroid cancer. This […]
LINK Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN. Thyroid. 2011 Apr 21. [PMID21510801) payday advance loans Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated with Negative Pregnancy Outcomes. Negro R , Schwartz A […]
Yim JH , Kim WB , Kim EY , Kim WG , Kim TY , Ryu JS , Gong G , Hong SJ , Shong YK J Clin Endocrinol Metab April, 2011 The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. This study evaluated the efficacy of the first […]
J Clin Endocrinol Metab. 2011 Feb;96(2):320-32. Epub 2011 Jan 14 Department of Medicine, Gutenberg University Medical Center, Langenbeckstrasse 1, Mainz 55131, Germany. Zang S, Ponto KA, Kahaly GJ. The administration of iv glucocorticoid pulses has been advocated as a treatment approach for patients with inflammatory and moderate to severe Graves’ orbitopathy (GO). This review offers […]