TOPIC: Graves' orbitopathy Title: Methylprednisolone pulse therapy for patients with moderately severe Graves' orbitopathy: a prospective, randomized, placebo-controlled study. Authors: Van Geest RJ, Sasim IV, Koppenschaar HP, Kalmann R, Stravers SN, Bijlsma WR, & Mourits MP . Reference: European Journal of Endocrinology 158: 229-237, 2008 Summary Background Glucocorticoids, administered through different routes, are a mainstay […]

TOPIC: Relapse of hyperthyroidism in Graves' disease patients after discontinuation of antithyroid drug therapy Title: The prevalence of transient thyrotoxicosis after antithyroid drug therapy (ATD) in patients with Graves' disease. Authors: Kubota S, Takata K, Arishima T, Ohye H, et al. Reference: Thyroid 18 (1): 63-66, 2008 Summary Background When transient hyperthyroidism occurs after antithyroid […]

TOPIC: Iodine requirements & fortification in pregnancy Title: Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency. Authors: Moleti MC, Lo Presti VP, Campolo MC, Mattina F, Galletti M, Mandolfino M, Violi MA, Giorgianni G, De Domenico D, Trimarchi F, & Vermiglio F . Reference: Journal of […]

TOPIC: Thyroid nodules Title: Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and avanced tumor stage. Authors: Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, & Chen H. Reference: Journal of Clinical Endocrinology & Metabolism 93: 809-814, 2008 Summary Context […]

TOPIC: Genetics of hypothalamic-pituitary axis Title: Heritability of serum TSH, free T4 and free T2 concentrations: a study of a large UK twin cohort. Authors: Panicker V, Wilson SG, Spector TD, Brown SJ, Falchi M, Richards JB, Surdulescu GL, Lim EM, Flectcher SJ, & Walsh JP. Reference: Clinical Endocrinology 68: 652-659, 2008 Summary Objective Thyroid […]

TOPIC: Dyshormonogenesis and congenital hypothyroidism Title: Mutations in the iodotyrosine deiodinase gene and hypothyroidism. Authors: Moreno JC, Klootwijk W, van Toor H, Pinto G, D'Alessandro M, L'ger A, Goudie D, Polak M, Gr'ters A, & Visser TJ. Reference: New England Journal of Medicine 358: 1811-1818, 2008 Summary Context DEHAL1 has been identified as the gene […]

TOPIC: Hashimoto's encephalopathy Title: Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes. Authors: Blanchin S, Coffin C, Viader F, Ruf J, Carayon P et al. Reference: Journal of Neuroimmunology 192: 13-20, 2007 Summary Background Hashimoto's encephalopathy is a rare and controversial neurological disorder, which is responsive to treatment with corticosteroids and associated […]

TOPIC: P endrin gene mutation induces poor organification, iodine retention & high deiodinase activity Title: Pendred syndrome in two Galician Families: insights into clinical phenotypes through cellular, genetic and molecular studies. Authors: Palos F, Garcia-Rendueles ME, Araujo-Vilar D, Obregon MJ, Calvo RM et al. Reference: Journal of Clinical Endocrinology & Metabolism 93: 267-277, 2008 Summary […]

TOPIC: Congenital central hypothyroidism Title: Role of the Thyrotropin-Releasing Hormone stimulation test in diagnosis of congenital central hypothyroidism in infants. Authors: V an Tijn DA, de Vijlder JJM, & Vulsma T. Reference: Journal of Clinical Endocrinology & Metabolism 93: 410-419, 2008 Summary Context A shortage of thyroid hormone during prenatal life and the first years […]

TOPIC: In primary neuron cultures (hippocampus), glutamatergic receptors are affected by thyroid hormones Title: Non genomic regulation of glutamatergic neurotransmission in hippocampus by thyroid hormones. Authors: Losi G, Garzon G, & Puia G. Reference: Neuroscience 151: 155-163, 2008 Summary Background Thyroid hormones (THs) are well known for their genomic effects but, recently, attention has focused […]

TOPIC: Patterning of retinal cone photoreceptor development Title: NeuroD1 regulates expression of thyroid hormone receptor '2 and cone opsins in the developing mouse retina. Authors: Liu H, Etter P, Hayes S, Jones I, Nelson B, Hartman B, Forrest D, & Reh T. Reference: The Journal of Neuroscience, 28: 749-756, 2008 Summary Objective The correct patterning […]

TOPIC: Free T4 measurements during pregnancy Title: Tandem mass spectrometry improves the accuracy of free T4 measurements during pregnancy. Authors: Kahric-Janicic N, Soldin SJ, Soldin OP, West T, Gu J, & Jonklaas J. Reference: Thyroid 17: 303-311, 2007 Summary Objective The aim of the study was to compare a new tandem mass spectrometric (LC/MS/MS) method […]

TOPIC: Thyroid hormone metabolism & action Title: Type 2 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Authors: Hernandez A, Martinez ME, Liao XH, Van Sande J, Refetoff S, Galton VA, & St Germain DL. Reference: Endocrinology 148: 5680-5687, 2007 Summary Background The type 3 deiodinase (D3) is a selenoenzyme […]

TOPIC: Thyroid development Title: Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Authors: : Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, & Rohr KB. Reference: Development 134: 2871-2879, 2007 (doi:10.1242/dev.02872) Summary Background In all vertebrates, the thyroid gland develops from the ventral […]

TOPIC: D yshormonogenesis due to mutations in DUOXA2 gene Title: Biallelic inactivation of the dual oxidase maturation factor 2 ( DUOXA2 ) gene as a novel cause of congenital hypothyroidism. Authors: Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, & Weber G. Reference: […]

TOPIC: Graves' orbitopathy Title: Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogues Authors: Cozma I, Zhang L, Uddin J, Lane C, Rees A, & Ludgate M Reference: Am J Physiol Endocrinol Metab 293: E1630-E1635, 2007 (ahead of print) Summary Background Treatment of Graves'orbitopathy (GO) with two somatostatin analogs, […]

TOPIC: Factors influencing thyroid volume in school-age children in an area with iodine sufficiency Title: Thyroid volume and echo-structure in school children living in an iodine-replete area: relation to age, pubertal stage, and body mass index. Authors: Kaloumenou I, Alevizaki M, Ladopoulos C, Antoniou A, Duntas LH, Mastorakos G, Chiotis D, Mengreli C, Livadas S, […]

TOPIC: Autoimmune thyroid disease during pregnancy Title: Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. Authors: Negro R , Formoso G , Mangieri T , Pezzarossa A , Dazzi D , & Hassan H. Reference: Journal of Clinical Endocrinology & Metabolism 91:2587-2591, 2007 Summary Background Euthyroid women with autoimmune […]

TOPIC: Methodological issues with serum thyroglobulin measurements Title: Comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients Authors: Schlumberger M, Hitzel A, Toubert ME, Corone C, et al. Reference: Journal of Clinical Endocrinology & Metabolism 92:2487-2495, 2007 Summary Objectives Serum thyroglobulin (Tg) is the most sensitive and specific […]

TOPIC:Subclinical hypo- and hyperthyroidism and mortality Title: Association between increased mortality and mild thyroid dysfunction in cardiac patients. Authors: Ievarsie G, Molinaro S, Landi P, Taddei MC, Galli E, Mariani F, L-Abbate A, & Pingitore A. Reference: Archives of Internal Medicine 167: 1526-1532, 2007 Summary Background The clinical relevance of subclinical hypothyroidism (SCH) and subclinical […]

TOPIC: Potential role of iron deficiency adversely affecting maternal thyroid function. Title: Iron deficiency predicts poor maternal thyroid status during pregnancy. Authors: Zimmerman MB, Burgi H, & Hurrell RF. Reference: Journal of Clinical Endocrinology & Metabolism 92: 3436-3440, 2007 Summary Background Pregnant women are often iron deficient during the 2 nd and 3 rd trimesters […]

TOPIC: A novel thyroid hormone analog with potential clinical use Title: Single-dose targeting of thyroid hormone receptor- agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Authors: Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang B-H, Hou J, Boyer SH, van Poelje PD, & Linemeyer DL. […]

TOPIC: A new type of mutation in the TSH receptor Title: A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca 2+ cascade mediates TSH action on thyroid hormone synthesis. Authors: Grasberger H , Van Sande J , Hag-Dahood MA , Tenenbaum-Rakover Y , & Refetoff S. Reference: Journal of Clinical […]

TOPIC: Knowledge concerning thyroid diseases and pregnancy Title: Thyroid disease and pregnancy: degrees of knowledge. Authors: Rinaldi MD & Stagnaro-Green AS. Reference: Thyroid 17: 747-753, 2007 Summary Objective The literature on the impact of thyroid abnormalities on pregnancy and the postpartum has expanded rapidly over the last two decades. Objective of present study was to […]

TOPIC: Graves-orbitopathy Title: Patients with severe Graves- ophthalmopathy have a higher risk of relapsing hyperthyroidism and are unlikely to remain in remission. Authors: Ecktsein AK, Lax H, Losch C, Glowacka D, Plicht M, Mann K, Esser J & Morgenthaler NG. Reference: Clinical Endocrinology 67: 607-612, 2007 Summary Background Graves- hyperthyroidism and orbitopathy (GO) are frequently […]